What factors influence the bacteria mutation rate?

What factors influence the bacteria mutation rate? The group at UCAM (Murray & Weinert et al) show that in Streptococcus suis, invasive disease strains have faster rates, while genome size has no effect. This work was published in PlOS Genetics. 

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Great collaborative work between IRTA and DTU scientists on the innate immune response of piglets to Streptococcus suis colonization

Piglet innate immune response to Streptococcus suis colonization is modulated by the virulence of the strain

A close collaboration between IRTA and DTU in work package 3 of the PIGSs project led to the important paper which has been published open access in Veterinary Research. 

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Important paper published by TiHo and DLO on the search for new therapeutics against streptococcal infections.

A PIGSs collaboration between the laboratories of TiHo (Hannover, DE) and DLO (Lelystad, NL) led to the identification of the mid-cell anchored protein Z (MapZ) which is involved in cell division in Streptococcus suis, an emerging zoonotic pathogen. The deletion of this gene leads to morphological growth defects including aberrant cell shapes and sizes as well as mispositioned division septa. Moreover, the absence of MapZ results in reduced biological fitness in the host.

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All S. suis virulence factors studied in experimental models of human origin in a systematic review and assessed their contribution to zoonotic potential in a subsequent genomic meta-analysis

The group of Prof. Schultsz and Dr. Van der Ark recently published a systematic review and genomic meta-analysis on the identification of Streptococcus suis putative zoonotic virulence factors.

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Active Human and Porcine Serum Induce Competence for Genetic Transformation Streptococcus suis

A recent scientific article has been published by the Host-Microbe-Interactions group at WUR on competence development for genetic transformation in the emerging zoonotic pathogen Streptococcus suis.

 

 

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Profile of Dr. Manouk Vrieling, WP leader of WP4 in the PIGSs project

 has been working at our institute for almost 2 years now: 'I study the interaction between bacteria and the host immune system in order to find new strategies to prevent diseases in livestock. For example, I’m working on vaccine development for Streptococcus suis. This bacterium is a common cause of serious illness such as meningitis in piglets. A vaccine would mean fewer infections, better animal welfare and less use of antibiotics.'

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Great paper: Comparative Virulence and Genomic Analysis of Streptococcus suis Isolates

A newly published report by Prof. Tracy Nicholson et al of the National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, provides a framework for future allelic replacement and/or functional genomic studies investigating genetic characteristics underlying the spectrum of disease outcomes caused by Streptococcus suis isolates.

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Interesting paper from the Hannover group on bordetella bronchiseptica promoting adherence, colonization, and cytotoxicity of Streptococcus suis in a porcine precision-cut lung slice model

Bordetella (B.) bronchiseptica and Streptococcus (S.) suis are major pathogens in pigs, which are frequently isolated from co-infections in the respiratory tract and contribute to the porcine respiratory disease complex (PRDC). Despite the high impact of co-infections on respiratory diseases of swine (and other hosts), very little is known about pathogen-pathogen-host interactions and the mechanisms of pathogenesis.

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Great paper on the ability of Streptococcus suis to genetically transform when cultured in active porcine and human serum.

The Wageningen University & Research group recently published ((Ferrando et al) in Pathogens about the competence of Streptococcus suis, an important zoonotic agent and porcine pathogen, for genetic transformation with plasmid or linear DNA when cultured in active porcine and human serum.

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Nice front cover page of our new COX-2 paper on results obtained within the PIGSs project

A figure in a recent paper published by the University of Veterinary Medicine Hannover based on work conducted in the PIGSs project was selected as cover page in Microorganisms, an open-access journal from MDPI. 

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