Results on in vivo transcriptomes of Streptococcus suis published in Virulence.

Principal Investigators from the Wageningen University groups of Animal Sciences and Host-Microbe Interactions jointly published their collaborative work on in vivo transcriptomes of Streptococcus suis in Virulence. 

Virulence is a peer reviewed medical journal that covers microbiology and immunology specifically, microorganism pathogenicity, the infection process and host–pathogen interactions.

Results of the collaborative project: Analysis of the bacterial transcriptome during infection provided valuable insights into the adaptation of S. suis to infection of the porcine host. Specific gene expression profiles were identified in brain, joint, and heart tissues or blood. Although many of the differentially expressed genes encode proteins previously proposed to be relevant for infection of the porcine host, many others were identified here for the first time including regulators, potential transporters, and integral membrane and secreted proteins without assigned functions. It will be important to investigate the role of these novel structures in future works. Their work highlights that the Strep. suis pathogen undergoes a rapid adaptive response that remodels bacterial metabolism and virulence, probably governed in part by a repertoire of differentially expressed transcriptional regulators. Clearly, different structures are differently required at specific niches in the process of dissemination and expansion of the disease.


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