Characterization of virulence genes in Streptococcus suis using CRISPRi and organoid models
Streptococcus suis is a bacterial pathogen which is a major cause of mortality and economic losses in the pig farming industry. Moreover, it is also a zoonotic pathogen causing human infections worldwide. Almost 100% of pig farms worldwide have carrier animals, but the factors leading to invasive disease are not well understood. Genetic variation within S. suis complicate the development of effective control strategies so that to date, no efficacious, cross-protective vaccines exist for S. suis. The overall aim of this research project is to unravel the host-pathogen interactions that take place during the infection process and thereby aid the development of effective vaccines, anti-virulence strategies and diagnostic tools to combat S. suis infections.